Clinical research laboratory used for hair loss evidence review

Clinical Evidence

Research & Science

Every treatment we offer is grounded in peer-reviewed science. Browse the clinical trials and mechanism studies that inform our approach.

[01]Evidence Overview©2026

Methods tracked

15

Papers indexed

133

Structured analyses

133

pharmacological

Minoxidil

Grade A

68 linked papers with evidence grade A. Best indexed study enrolled 466 participants.

Papers

68

Participants

8,296

Headline

28.58 % avg effect

pharmacological

Finasteride

Grade B

49 linked papers with evidence grade B. Best indexed study enrolled 4495 participants.

Papers

49

Participants

13,239

Headline

87.23 hairs avg effect

device

PRP

Grade A

34 linked papers with evidence grade A. Best indexed study enrolled 2888 participants.

Papers

34

Participants

6,228

Headline

28.54 hairs/cm2 avg effect

lifestyle

General Hair Loss

Grade B

30 linked papers with evidence grade B. Best indexed study enrolled 2888 participants.

Papers

30

Participants

3,045

Headline

68.25 % avg effect

device

Low-Level Laser Therapy

Grade B

29 linked papers with evidence grade B.

Papers

29

Participants

5,290

Headline

13.12 hairs/cm² avg effect

pharmacological

Dutasteride

Grade B

24 linked papers with evidence grade B. Best indexed study enrolled 4495 participants.

Papers

24

Participants

11,118

Headline

26.5 % avg effect

surgical

Hair Transplant

Grade B

21 linked papers with evidence grade B.

Papers

21

Participants

146

Headline

89 % avg effect

device

Microneedling

Grade A

15 linked papers with evidence grade A. Best indexed study enrolled 466 participants.

Papers

15

Participants

1,633

Headline

62.4 % avg effect

pharmacological

Ketoconazole

Grade B

12 linked papers with evidence grade B. Best indexed study enrolled 4566 participants.

Papers

12

Participants

5,065

Headline

100 % avg effect

supplement

Saw Palmetto

Grade B

11 linked papers with evidence grade B. Best indexed study enrolled 80 participants.

Papers

11

Participants

140

Headline

29 % reduction in hair fall avg effect

device

Stem Cell Therapy

Grade C

8 linked papers with evidence grade C. Best indexed study enrolled 2888 participants.

Papers

8

Participants

2,888

Headline

68.4 % avg effect

supplement

Biotin

Grade B

7 linked papers with evidence grade B. Best indexed study enrolled 50 participants.

Papers

7

Participants

224

Headline

23 % avg effect

pharmacological

Spironolactone

Grade B

7 linked papers with evidence grade B. Best indexed study enrolled 5290 participants.

Papers

7

Participants

5,320

Headline

26.5 % avg effect

device

Exosome Therapy

Grade C

2 linked papers with evidence grade C.

Papers

2

Participants

N/A

Headline

Structured extraction limited

pharmacological

DHT Pathway

Grade C

1 linked papers with evidence grade C.

Papers

1

Participants

N/A

Headline

promising qualitative assessment best indexed study

[02]All Papers©2026
GeneralGeneral Hair Loss
Scalp Microbiome Alterations in Androgenetic Alopecia: Patterns and Emerging Mechanistic Insights.

Gupta AK, Teasell EM, Liddy A, Economopoulos V · International journal of dermatology · 2026

Alterations in the scalp microbiome, particularly enrichment of Cutibacterium acnes and Malassezia, may contribute to AGA pathogenesis via lipid-immune interactions, suggesting potential benefit from lipid-modulating agents such as ketoconazole.

Study

review

Population

N/A

Key result

Pending extraction

Citations

N/A

Confidence

low

Tags

condition:androgenetic_alopecia, sex:mixed, population:adult

Saw PalmettoSaw Palmetto
Herbal Remedies for Hair Loss: A Review of Efficacy and Safety.

Ahmed A, Alali AM, Abdullah E, Alharbi MN, Alayoubi HM · Skin appendage disorders · 2026

Herbal remedies such as saw palmetto, rosemary, and others show promise for promoting hair growth in various types of hair loss via mechanisms like 5α-reductase inhibition and increased microcirculation, though evidence is limited.

Study

review

Population

N/A

Key result

Pending extraction

Citations

N/A

Confidence

low

Tags

condition:androgenetic_alopecia, condition:telogen_effluvium, condition:alopecia_areata

FinasteridePRPMinoxidil
A Prospective and Comparative Study to Explore the Effects of Platelet-Rich Plasma in Hair Transplantation for Patients With Androgenetic Alopecia.

Xue P, Guo L, Dang E, Dou W, Zeng X, Fan X, Yang Q · Journal of cosmetic dermatology · 2025

Combining PRP with pharmacological support during FUE hair transplantation significantly improves follicle survival, growth rates, and hair strength compared to pharmacological support alone.

Study

rct

Population

30 participants

Key result

significantly improved follicle growth rates

Citations

N/A

Confidence

low

Tags

condition:androgenetic_alopecia, population:adult, outcome:hair_regrowth

MinoxidilMinoxidilPRP
Effects of platelet-rich plasma application on hair follicle count, telogen/anagen ratio, and miniaturized hair ratio in patients with androgenic alopecia: alone or in combination with other treatments.

Koç Babayiğit F, Kartal D, Çinar SL, Borlu M · The Journal of dermatological treatment · 2025

PRP alone and in combination with minoxidil significantly improved hair count, density, terminal hair count, and increased the anagen ratio; the combination also significantly reduced vellus hair count and density.

Study

cohort

Population

45 participants

Key result

Pending extraction

Citations

N/A

Confidence

moderate

Tags

condition:androgenetic_alopecia, sex:mixed, population:adult

PRPPRPMicroneedling
Phase I Clinical Trial: Evaluating the Efficacy, Safety, and Patient Satisfaction of Platelet-Rich Plasma (PRP) Injections and Microneedling for Androgenetic Alopecia Treatment.

Nilforoushzadeh MA, Roohaninasab M, Behrangi E, Jafarzadeh A, Nouri M, Zare S, Zare S · Journal of cosmetic dermatology · 2025

Both PRP injections and microneedling significantly increased hair count and thickness after two months, with microneedling showing a greater percent increase in hair count (88.4% vs 62.4%) and PRP showing a slightly greater increase in hair thickness (58.6% vs 51.3%).

Study

rct

Population

40 participants

Key result

62.4% %

Citations

N/A

Confidence

moderate

Tags

condition:androgenetic_alopecia, sex:male, sex:female

MinoxidilMinoxidilLow-Level Laser Therapy
Comparative efficacy of minoxidil alone versus minoxidil combined with low-level laser therapy in the treatment of androgenic alopecia: a systematic review and meta-analysis.

Alosaimi A, Algarni A, Alharbi A, Alotaibi A, Alomairi A, Alsurayhi M, Alharbi W · The Journal of dermatological treatment · 2025

Combining minoxidil with low-level laser therapy did not produce a statistically significant improvement in hair count or hair diameter compared to minoxidil alone in patients with androgenic alopecia.

Study

meta analysis

Population

N/A

Key result

-0.04 hairs/cm²

Citations

N/A

Confidence

moderate

Tags

condition:androgenetic_alopecia, sex:mixed, population:adult

FinasterideFinasterideMinoxidil
Androgenetic alopecia.

Liu Y, Tosti A, Wang ECE, Heilmann-Heimbach S, Aguh C, Jimenez F, Lin SJ, Kwon O, Plikus MV · Nature reviews. Disease primers · 2025

Established therapies such as oral finasteride, topical minoxidil, and hair transplantation can reduce hair loss and promote regrowth in many patients, although response varies and novel approaches are needed.

Study

review

Population

N/A

Key result

>380 genomic loci

Citations

N/A

Confidence

high

Tags

condition:androgenetic_alopecia, condition:male_pattern_hair_loss, condition:female_pattern_hair_loss

MinoxidilLow-Level Laser TherapyMinoxidil
Comparative efficacy and safety of low-level laser therapy and topical Minoxidil combination vs. topical Minoxidil monotherapy in androgenetic alopecia management: a systematic review and meta-analysis of randomized controlled trials.

Mawu FO, Sondakh ORL, Kairupan TS, Christopher PM · Lasers in medical science · 2025

Combination LLLT and minoxidil produced significantly greater increases in hair density and hair shaft diameter, and higher patient satisfaction, compared to minoxidil monotherapy.

Study

meta analysis

Population

N/A

Key result

6.62 hairs/cm²

Citations

N/A

Confidence

moderate

Tags

condition:androgenetic_alopecia, sex:mixed, population:adult

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